Plasma Exosome Analysis for Protein Mutation Identification Using a Combination of Raman Spectroscopy and Deep Learning

Seungmin Kim, Byeong Hyeon Choi, Hyunku Shin, Kihun Kwon, Sung Yong Lee, Hyun Bin Yoon, Hyun Koo Kim*, and Yeonho Choi*

ACS Sensors

Permanent Anticoagulation Blood-Vessel by Mezzo-Sized Double Re-Entrant Structure

Dongkwon Seo, Yang Hyun Cho, Gijung Kim, Hyunku Shin, Su Kyoung Lee, Ji Eon Kim, Honggu Chun, Jae Seung Jung, Yeonho Choi

Small

Selected as Front Cover

Artificial Intelligence-Based Major Depressive Disorder (MDD) Diagnosis Using Raman Spectroscopic Features of Plasma Exosomes

Hyunku Shin, Youbin Kang, Kwan Woo Choi, Seungmin Kim, Byung-Joo Ham, and Yeonho Choi

Analytical Chemistry

Selected as Front Cover

Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers

Hyunku Shin, Byeong Hyeon Choi, On Shim, Jihee Kim, Yong Park, Suk Ki Cho, Hyun Koo Kim & Yeonho Choi

Nature communications

Jones Matrix Microscopy for Living Eukaryotic Cells

Kwanjun Park, Taeseok Daniel Yang, Dongkwon Seo, Min Gyu Hyeon, Taedong Kong, Beop-Min Kim, Yeonho Choi, Wonshik Choi, Youngwoon Choi

ACS Photonics

GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer

Hyesun Jeong, Byeong Hyeon Choi, JinA Park, Jik-Han Jung, Hyunku Shin, Ka-Won Kang, Yu Hua Quan, Jewon Yu, Ji-Ho Park, Yong Park, Yeonho Choi, Hyun Koo Kim, Sunghoi Hong

Cancers

Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy

Hyosuk Kim, Hochung Jang, Haeun Cho, Jiwon Choi, Kwang Yeon Hwang, Yeonho Choi, Sun Hwa Kim, Yoosoo Yang

Cancers

Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

Luize G. Lima, Sunyoung Ham, Hyunku Shin, Edna P. Z. Chai, Erica S. H. Lek, Richard J. Lobb, Alexandra F. Müller, Suresh Mathivanan, Belinda Yeo, Yeonho Choi, Belinda S. Parker, Andreas Möller

Nature communications

Dynamic Metallization of Spherical DNA via Conformational Transition into Gold Nanostructures with Controlled Sizes and Shapes

Won Kyu Lee, Kihun Kwon, Yeonho Choi, Jae-Seung Lee

Journal of Colloid and Interface Science

Dual size-exclusion chromatography for efficient isolation of extracellular vesicles from bone marrow derived human plasma

Jik-Han Jung, Woojin Back, Junyong Yoon, Hyeonjeong Han, Ka-Won Kang, Byeonghyeon Choi, Hyesun Jeong, Jaena Park, Hyunku Shin, Woojune Hur, Yeonho Choi, Sunghoi Hong, Hyun Koo Kim, Yong Park, Ji-Ho Park

Scientific Reports

A proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia

Ka-Won Kang, Hyoseon Kim, Woojune Hur, Jik-han Jung, Su Jin Jeong, Hyunku Shin, Dongkwon Seo, Hyesun Jeong, ByeongHyeon Choi, Sunghoi Hong, Hyun Koo Kim, Yeonho Choi, Ji-ho Park, Kil Yeon Lee, Kwang Pyo Kim, Yong Park

Molecular & Cellular Proteomics

Extracellular Vesicle Identification Using Label-Free Surface-Enhanced Raman Spectroscopy: Detection and Signal Analysis Strategies

Hyunku Shin, Dongkwon Seo, Yeonho Choi

Molecules

Evaluation of intraoperative near-infrared fluorescence visualization of the lung tumor margin with indocyanine green inhalation

Yu Hua Quan, Chan Hee Oh, Daeho Jung, Ji-Young Lim, Byeong Hyeon Choi, Jiyun Rho, Yeonho Choi, Kook Nam Han, Beop-Min Kim, Chungyeul Kim, Ji-Ho Park, Hyun Koo Kim

JAMA surgery

Levels of Extracellular Vesicles in Pulmonary and Peripheral Blood Correlate with Stages of Lung Cancer Patients.

Byeong Hyeon Choi, Yu Hua Quan, Jiyun Rho, Sunghoi Hong, Yong Park, Yeonho Choi, Ji-Ho Park, Hwan Seok Yong, Kook Nam Han, Young Ho Choi, Hyun Koo Kim

World Journal of Surgery

Early-Stage Lung Cancer Diagnosis by Deep Learning-Based Spectroscopic Analysis of Circulating Exosomes

Hyunku Shin, Seunghyun Oh, Soonwoo Hong, Minsung Kang, Daehyeon Kang, Yong-gu Ji, Byeong Hyeon Choi, Ka-Won Kang, Hyesun Jeong, Yong Park, Sunghoi Hong, Hyun Koo Kim, Yeonho Choi

ACS nano

Protein Quantification and Imaging by Surface‐Enhanced Raman Spectroscopy and Similarity Analysis

Hyunku Shin, Seunghyun Oh, Daehyeon Kang, Yeonho Choi

Advanced Science

Selected as Front Cover

Wrapping AgCl Nanostructures with Trimetallic Nanomeshes for Plasmon-Enhanced Catalysis and in Situ SERS Monitoring of Chemical Reactions

Han-Jung Ryu, Hyunku Shin, Seunghyun Oh, Jang Ho Joo, Yeonho Choi, Jae-Seung Lee

ACS Applied Materials & Interfaces

Red blood cell and white blood cell separation using a lateral-dimension scalable microchip based on hydraulic jump and sedimentation

Hamidreza Shirinkami, Gaobo Wang, Jinhyeok Park, Joonhyang Ahn, Yeonho Choi, Honggu Chun

Sensors and Actuators B: Chemical

Quantum biological tunnel junction for electron transfer imaging in live cells

Hongbao Xin, Wen Jing Sim, Bumseok Namgung, Yeonho Choi, Baojun Li, Luke P Lee

Nature communications

Aqueous synthesis of highly monodisperse sub-100 nm AgCl nanospheres/cubes and their plasmonic nanomesh replicas as visible-light photocatalysts and single SERS probes

Jang Ho Joo, Hyunku Shin, Kihun Kwon, Soonwoo Hong, Han-Jung Ryu, Yeonho Choi, Jae-Seung Lee

Nanotechnology

Identification of newly emerging influenza viruses by detecting the virally infected cells based on surface enhanced Raman spectroscopy and principal component analysis

Jae-young Lim, Jung-soo Nam, Hyunku Shin, Jaena Park, Hye-in Song, Minsung Kang, Kwang-il Lim, Yeonho Choi

Analytical chemistry

Selected as Cover

Flexible and stable omniphobic surfaces based on biomimetic repulsive air-spring structures

Dongkwon Seo, Suk-kyong Cha, Gijung Kim, Hyunku Shin, Soonwoo Hong, Yang Hyun Cho, Honggu Chun, Yeonho Choi

ACS applied materials & interfaces

Self-targeted knockdown of CD44 improves cisplatin sensitivity of chemoresistant non-small cell lung cancer cells

Yu Hua Quan, Ji-Young Lim, Byeong Hyeon Choi, Yeonho Choi, Young Ho Choi, Ji-Ho Park, Hyun Koo Kim

Cancer chemotherapy and pharmacology

Correlation between cancerous exosomes and protein markers based on surface-enhanced Raman spectroscopy (SERS) and principal component analysis (PCA)

Hyunku Shin, Hyesun Jeong, Jaena Park, Sunghoi Hong, Yeonho Choi

ACS sensors

Selected as Cover

3D Assembly of Metal Nanoparticles at Oleic Acid/Water Interface via Their Autonomous and Rapid Interfacial Locomotion

Yonghee Shin, Keumrai Whang, Jeehan Chang, Jungwoo Jang, Sooyeon Yoo, Jungchul Lee, Yeonho Choi, Inhee Choi, Taewook Kang

Advanced Materials Interfaces

The Potential of Exosomes Derived from Chronic Myelogenous Leukaemia Cells as a Biomarker

Ka-won Kang, Jik-han Jung, Woojune Hur, Jaena Park, Hyunku Shin, Byeonghyeon Choi, Hyesun Jeong, Dae Sik Kim, Eun Sang Yu, Se Ryeon Lee, Hwa Jung Sung, Seok Jin Kim, Chul Won Choi, Hyun Koo Kim, Sunghoi Hong, Ji-ho Park, Yeonho Choi, Yong Park, Byung Soo Kim

Anticancer Research

Precise nanoinjection delivery of plasmid DNA into a single fibroblast for direct conversion of astrocyte

Hang-Soo Park, Hyosung Kwon, Jewon Yu, Yeonju Bae, Jae-Yong Park, Kyung-Ah Choi, Yeonho Choi, Sunghoi Hong

Artificial Cells, Nanomedicine, and Biotechnology

Exosome classification by pattern analysis of surface-enhanced Raman spectroscopy data for lung cancer diagnosis

Jaena Park, Miyeon Hwang, ByeongHyeon Choi, Hyesun Jeong, Jik-han Jung, Hyun Koo Kim, Sunghoi Hong, Ji-ho Park, Yeonho Choi

Analytical chemistry

Stem cell transplantation for Huntington’s diseases

Kyung-Ah Choi, Yeonho Choi, Sunghoi Hong

Methods

Femtoliter scale quantitative injection control by experimental and theoretical modeling

Jewon Yu, Hyosung Kwon, Hang-soo Park, Sunghoi Hong, Yeonho Choi

Biomedical Engineering Letters

In-Plate and On-Plate Structural Control of Ultra-Stable Gold/Silver Bimetallic Nanoplates as Redox Catalysts, Nanobuilding Blocks, and Single-Nanoparticle Surface-Enhanced Raman Scattering Probes

Ju-Hwan Oh, Hyunku Shin, Jong Yun Choi, Hee Won Jung, Yeonho Choi, Jae-Seung Lee

ACS applied materials & interfaces

Macrophage-targeted indocyanine green-neomannosyl human serum albumin for intraoperative sentinel lymph node mapping in porcine esophagus

Hyun Koo Kim, Yu Hua Quan, Yujin Oh, Ji Yong Park, Ji-Ho Park, Yeonho Choi, Yun-Sang Lee, Jae Min Jeong, Young Ho Choi, Beop-Min Kim

The Annals of thoracic surgery

Intraoperative pulmonary neoplasm identification using near-infrared fluorescence imaging

Hyun Koo Kim, Yu Hua Quan, Byeong Hyeon Choi, Ji-Ho Park, Kook Nam Han, Yeonho Choi, Beop-Min Kim, Young Ho Choi

European Journal of Cardio-Thoracic Surgery

Autoenhanced Raman spectroscopy via plasmonic trapping for molecular sensing

Soonwoo Hong, On Shim, Hyosung Kwon, Yeonho Choi

Analytical chemistry

Identification of newly emerging influenza viruses by surface-enhanced Raman spectroscopy

Jae-young Lim, Jung-soo Nam, Se-eun Yang, Hyunku Shin, Yoon-ha Jang, Gyu-Un Bae, Taewook Kang, Kwang-il Lim, Yeonho Choi

Analytical chemistry

Spatio-temporally controlled transfection by quantitative injection into a single cell

Hyosung Kwon, Hang-soo Park, Jewon Yu, Sunghoi Hong, Yeonho Choi

Biomaterials

Highly sensitive and selective anticancer effect by conjugated HA-cisplatin in non-small cell lung cancer overexpressed with CD44

Yu Hua Quan, Byungji Kim, Ji-Ho Park, Yeonho Choi, Young Ho Choi, Hyun Koo Kim

Experimental lung research

Graphene nanopore with a self-integrated optical antenna

SungWoo Nam, Inhee Choi, Chi-cheng Fu, Kwanpyo Kim, SoonGweon Hong, Yeonho Choi, Alex Zettl, Luke P Lee

Nano letters

Exosome identification for personalized diagnosis and therapy

Jaena Park, Yeonho Choi

Biomedical Engineering Letters

Photothermal inhibition of neural activity with near-infrared-sensitive nanotransducers

Sangjin Yoo, Soonwoo Hong, Yeonho Choi, Ji-Ho Park, Yoonkey Nam

ACS nano

Asymmetrically coupled plasmonic core and nanotriplet satellites

Hanggochnuri Jo, Daesung Yoon, Ahrum Sohn, Dong-Wook Kim, Yeonho Choi, Taewook Kang, Dukhyun Choi, Sang-Woo Kim, Luke P Lee

The Journal of Physical Chemistry C

Retinal pigment epithelial cells undergoing mitotic catastrophe are vulnerable to autophagy inhibition

SY Lee, JS Oh, JH Rho, NY Jeong, YH Kwon, WJ Jeong, WY Ryu, HB Ahn, WC Park, SH Rho, YG Yoon, SY Jeong, YH Choi, HY Kim, YH Yoo

Cell death & disease

Thoracoscopic Color and Fluorescence Imaging System for Sentinel Lymph Node Mapping in Porcine Lung Using Indocyanine Green-Neomannosyl Human Serum Albumin: Intraoperative Image-Guided Sentinel Nodes Navigation

Yujin Oh, Yun-Sang Lee, Yu Hua Quan, Yeonho Choi, Jae Min Jeong, Beop-Min Kim, Hyun Koo Kim

Annals of surgical oncology

Intraoperative combined color and fluorescent images–based sentinel node mapping in the porcine lung: Comparison of indocyanine green with or without albumin premixing

Yujin Oh, Yu Hua Quan, Yeonho Choi, Choong Ki Kim, Heezoo Kim, Hyun Koo Kim, Beop-Min Kim

The Journal of thoracic and cardiovascular surgery

In-situ nanospectroscopic pH monitoring by plasmon resonance energy transfer (PRET)

Hyunku Shin, Jaemin Baek, Hyosung Kwon, Yeonho Choi

Journal of Nanoscience and Nanotechnology

Self-assembled three-dimensional nanocrown array

Soongweon Hong, Taewook Kang, Dukhyun Choi, Yeonho Choi, Luke P Lee

ACS nano

Three-dimensional reduced-symmetry of colloidal plasmonic nanoparticles

Eunhye Jeong, Kihoon Kim, Inhee Choi, Sunil Jeong, Younggeun Park, Hyunjoo Lee, Soo Hong Kim, Luke P Lee, Yeonho Choi, Taewook Kang

Nano letters

Nanowire-based single-cell endoscopy

Ruoxue Yan, Ji-Ho Park, Yeonho Choi, Chul-Joon Heo, Seung-Man Yang, Luke P Lee, Peidong Yang

Nature nanotechnology

Robust plasmonic sensors based on hybrid nanostructures with facile tunability

Chul-Joon Heo, Hwan Chul Jeon, Su Yeon Lee, Se Gyu Jang, Soojeong Cho, Yeonho Choi, Seung-Man Yang

Journal of Materials Chemistry

Plasmonic nanosensors: review and prospect

Inhee Choi, Yeonho Choi

IEEE Journal of Selected Topics in Quantum Electronics

Simultaneous optical monitoring of the overgrowth modes of individual asymmetric hybrid nanoparticles

Young In Yang, Eunhye Jeong, Inhee Choi, Suseung Lee, Hyeon Don Song, Kihoon Kim, Yeonho Choi, Taewook Kang, Jongheop Yi

Angewandte Chemie

The effect of thermal gradients in SERS spectroscopy

Taewook Kang, Soongweon Hong, Yeonho Choi, Luke P Lee

Small

Study of microscale hydraulic jump phenomenon for hydrodynamic trap-and-release of microparticles

Younggeun Park, Yeonho Choi, Debkishore Mitra, Taewook Kang, Luke P Lee

Applied physics letters

Self‐organized hexagonal‐nanopore SERS array

Dukhyun Choi, Yeonho Choi, Soongweon Hong, Taewook Kang, Luke P Lee

Small

Metal–Insulator–Metal Optical Nanoantenna with Equivalent‐Circuit Analysis

Yeonho Choi, Dukhyun Choi, Luke P Lee

Advanced Materials

Shadow overlap ion-beam lithography for nanoarchitectures

Yeonho Choi, Soongweon Hong, Luke P Lee

Nano letters

Selective and sensitive detection of metal ions by plasmonic resonance energy transfer-based nanospectroscopy

Yeonho Choi, Younggeun Park, Taewook Kang, Luke P Lee

Nature nanotechnology

Noninvasive Real-time Monitoring of Amyloid-β Fibrillization via Simultaneous Label-free Dielectric Relaxation Spectroscopy and Dark-Field Imaging

Yeonho Choi, Soongweon Hong, Taewook Kang, Luke P Lee

The Journal of Physical Chemistry C

Plasmon Resonance Energy Transfer (PRET)-based Molecular Imaging of Cytochrome c in Living Cells

Yeonho Choi, Taewook Kang, Luke P Lee

Nano letters

Additional amplifications of SERS via an optofluidic CD-based platform

Dukhyun Choi, Taewook Kang, Hansang Cho, Yeonho Choi, Luke P Lee

Lab on a Chip

Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer

Gang Logan Liu, Yi-Tao Long, Yeonho Choi, Taewook Kang, Luke P Lee

Nature Methods